Abstracting and Indexing

• PubMed NLM
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• WorldCat
• ResearchGate
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• Microsoft Academic
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Introduction: Regenerative surgery, an approach that merges stem cell science with tissue engineering has demonstrated strong potential to improve healing in trauma and oncologic patients. This review distills recent progress in stem cell therapies and engineering techniques, focusing on their use in repairing damaged tissues and organs during trauma and cancer operations.

Methods: An exhaustive literature search collated data from preclinical studies and clinical trials assessing stem cell–based therapies and tissue engineered constructs in trauma and cancer surgery. Extracted variables included stem cell type, regenerative outcomes, and safety profiles.

Results: Current evidence shows that mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs) can regenerate bone, cartilage, muscle, and nerve tissue. Biodegradable scaffolds and three dimensional bioprinting have enabled fabrication of functional tissue substitutes. Notable advances have been reported in bone healing, wound repair, and nerve regeneration; however, immune rejection, tumorigenic risk, and the challenge of scaling engineered tissues remain unresolved.

Conclusion: Regenerative surgery could markedly enhance outcomes for trauma and cancer patients, but ethical issues, technical limitations, and regulatory obstacles must be overcome before widespread clinical adoption.