Abstracting and Indexing

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Introduction: Postoperative infections and impaired wound healing remain major challenges in abdominal surgery. The gut microbiome has emerged as a crucial modulator of immune responses and tissue repair. This study evaluated the feasibility and safety of intraoperative targeted microbiota translocation to improve postoperative outcomes.

Methods: A prospective single-center feasibility study was conducted at Katihar Medical College, Katihar, including 20 patients undergoing elective major abdominal surgery. A sterile bacterial consortium containing Lactobacillus rhamnosus, Bifidobacterium longum, and Akkermansia muciniphila was infused directly into the proximal jejunum intraoperatively. Primary outcomes included feasibility and safety; secondary outcomes assessed postoperative infection rates, wound healing, inflammatory markers, and gut microbiota composition.

Results: Intraoperative microbiota translocation was achieved in all patients without technical difficulties or immediate adverse effects. Post-surgical infection occurred in 10 % of cases, notably lower than the institution’s historical rate of 22 %. The mean wound epithelialization time was 10.5 ± 1.8 days, and the average length of hospital stay was 8.7 ± 2.1 days. Serum CRP and IL-6 levels fell significantly by postoperative day 7. Microbiome analysis demonstrated an increased abundance of beneficial bacteria and greater overall diversity. No anastomotic leaks or readmissions were recorded within 30 days.

Conclusion: Targeted intraoperative microbiota translocation appears feasible and safe, showing promising reductions in postoperative infection, accelerated wound healing, and restoration of the gut microbiome.