Abstracting and Indexing

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Introduction: Successful aging encompasses the maintenance of functional independence, physical vitality, and cognitive integrity beyond chronological age. Mitochondrial resilience, reflecting the ability of mitochondria to adapt and maintain function under stress, has emerged as a potential biomarker for healthy aging. However, data from Indian elderly populations remain limited. This study aims to evaluate mitochondrial resilience as a predictor of successful aging among older adults in India and to explore its association with physical, cognitive, and inflammatory profiles.

Methods: A cross-sectional study was conducted among 200 elderly participants (≥65 years) at Patna Medical College. Participants were categorized into high- and low-functioning groups based on comprehensive geriatric assessments. Peripheral blood was analyzed for mtDNA copy number, mitochondrial membrane potential, ATP production, reactive oxygen species levels, and expression of biogenesis markers (PGC-1α, NRF1, TFAM). Serum inflammatory cytokines and telomere length were also measured.

Results: High-functioning individuals demonstrated significantly higher mtDNA copy numbers, preserved membrane potential, elevated ATP production, and lower oxidative stress markers. Enhanced expression of mitochondrial biogenesis proteins and a more favorable cytokine profile (lower IL-6, TNF-α; higher IL10) were observed in this group. Telomere length correlated positively with mitochondrial metrics, suggesting integrated genomic stability.

Conclusion: Mitochondrial resilience is strongly associated with successful aging and offers promise as a predictive biomarker for functional capacity in the elderly Indian population.