Abstracting and Indexing

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Often leading in death and long-term disability, traumatic brain injury (TBI) continues to be a serious global public health concern. One of the most prevalent and serious forms of brain damage is diffuse axonal injury (DAI), which is brought about by shearing stresses damaging the white matter of the brain. Unfortunately, conventional imaging techniques like routine MRI or CT scans often miss this kind of damage. Recently, diffusion tensor imaging (DTI), an advanced MRI approach, has shown great promise in detecting small changes in the brain's microstructure after injury. Covered are its working, position within clinical practice, advantages and disadvantages as well as its present application in the evaluation of TBI.

According to a thorough analysis of peer-reviewed studies published between 2005 and 2024, DTI outperforms other imaging modalities in detecting white matter abnormalities, especially in instances of slight TBI where other scans seem normal. Quantitative DTI measurements, like fractional anisotropy (FA) and mean diffusivity (MD), are often altered in individuals with TBI and have shown strong links with cognitive and functional results. DTI enhances existing imaging methods by offering better knowledge of the mechanisms of brain damage and holds promise as a biomarker to assess the extent of injury and forecast recovery.