Indian Journal of Innovative Clinical Research

Submit Manuscript

Journal Menu


Abstracting and Indexing

  • PubMed NLM
  • Google Scholar
  • Semantic Scholar
  • Scilit
  • CrossRef
  • WorldCat
  • ResearchGate
  • Academic Keys
  • DRJI
  • Microsoft Academic
  • Academia.edu
  • OpenAIRE
  • Scribd
  • Baidu Scholar

Unmasking Occult Multiple Myeloma Through Spontaneous Vertebral Compression Fractures in a Middle-Aged Diabetic Male: A Diagnostic Pitfall in Primary Care

Article Information


Mohammed Shamoon Khan

Multiple myeloma often creeps in under the guise of everyday musculoskeletal complaints, delaying diagnosis in busy primary-care clinics. We recount the case of a 56-year-old man with long-standing type 2 diabetes who came to his family physician with gradually worsening mid-back pain and pervasive fatigue over two months. Treated at first as simple mechanical back strain with analgesics, he deteriorated; spinal imaging ultimately revealed spontaneous vertebral compression fractures. Routine blood tests then uncovered normocytic, normochromic anaemia, hypercalcaemia and a raised total-protein level with a low albumin-to-globulin ratio. Serum protein electrophoresis and immunofixation identified a monoclonal band, and bone-marrow biopsy confirmed multiple myeloma. This case highlights the need to keep malignancy on the differential when otherwise unexplained musculoskeletal pain is paired with systemic “red flags” such as anaemia or hypercalcaemia. Prompt imaging and a targeted laboratory work-up can prevent misdiagnosis and secure an early oncology referral, ultimately improving patient outcomes.