Indian Journal of Innovative Clinical Research

Submit Manuscript

Journal Menu


Abstracting and Indexing

  • PubMed NLM
  • Google Scholar
  • Semantic Scholar
  • Scilit
  • CrossRef
  • WorldCat
  • ResearchGate
  • Academic Keys
  • DRJI
  • Microsoft Academic
  • Academia.edu
  • OpenAIRE
  • Scribd
  • Baidu Scholar

Diffusion-Weighted MRI as an Early Predictor of Neoadjuvant Chemotherapy Response in Locally Advanced Breast Cancer: A Longitudinal Study

Article Information

Mohd. Zubair

Background: Early assessment of reaction to neoadjuvant chemotherapy (NACT) is essential in handling regionally advanced breast most cancers (LABC). conventional imaging modalities are constrained in detecting early microstructural modifications. Diffusion-weighted magnetic resonance imaging (DW-MRI), through quantitative dimension of the apparent diffusion coefficient (ADC), gives a non-invasive approach to screen early remedy response.

Objective: To assess the efficacy of DW-MRI, especially serial ADC modifications, as an early predictor of pathological response to NACT in patients with LABC.

Method: This became a prospective, longitudinal study regarding 82 girl sufferers with biopsy-showed LABC at Katihar scientific college, Bihar. All sufferers underwent DW-MRI at baseline, publish-first NACT cycle, and submit-treatment of entirety. ADC values were recorded and correlated with pathological response put up-surgery. information had been analyzed the usage of paired t-tests, ROC curves, and subgroup analysis.

Result: Sufferers who performed pathological whole response (pCR) showed a appreciably higher boom in ADC values after the primary chemotherapy cycle compared to non-responders (31.2% vs. 17.eight%, p < 0.001). An early ADC growth of ≥25% anticipated pCR with 82.1% sensitivity and 79.6% specificity. DW-MRI showed excessive reproducibility (ICC = 0.88–0.ninety three) and stronger correlation with pathological reaction than tumor size reduction by myself. HER2-enriched and triple-terrible subtypes exhibited extra ADC shifts and higher pCR rates.

Conclusions: DW-MRI is a sensitive, reproducible, and comparison-loose tool for early prediction of NACT response in LABC. ADC kinetics offer valuable insights into tumor biology and might facilitate adaptive remedy strategies in breast most cancers management.