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The Impact of Preoperative Gut Microbiome Profiling on Postoperative Recovery and Surgical Site Infection Rates in Elective Abdominal Surgeries
Article Information
Background: The intestine microbiome has emerged as a crucial determinant of immune function and surgical consequences. but, its role in predicting postoperative recuperation and infection threat in belly surgeries remains underexplored. Objective: to assess the affiliation between preoperative intestine microbiome composition and postoperative outcomes, along with surgical web site infections (SSIs) and recuperation metrics—in sufferers present process elective abdominal surgical procedures. Methods: A potential observational have a look at became conducted at Katihar medical college involving 82 sufferers scheduled for optional belly surgeries. Preoperative stool samples had been gathered for 16S rRNA gene sequencing. Microbial variety indices and taxonomic composition were analyzed using QIIME2. Postoperative results, including time to bowel healing, health facility live, and prevalence of SSIs, were recorded. Multivariate logistic regression became used to pick out predictors of SSIs. Results: Eighteen sufferers (21.9%) developed SSIs. These patients exhibited notably lower microbial alpha diversity (mean Shannon index: 3.54 vs. 4.38, p < 0.001) and increased relative abundance of Enterococcus faecalis and Escherichia coli. Patients with higher levels of Faecalibacterium prausnitzii and Bifidobacterium adolescentis experienced faster bowel recovery and shorter hospital stays. Low microbial diversity, obesity, and presence of pathogenic taxa were independent predictors of SSIs. Conclusion: Preoperative gut microbiome profiling exhibits significant institutions among microbial variety and postoperative recovery in optionally available abdominal surgeries. those findings advise that gut microbiome characteristics can also function predictive biomarkers and capability targets for preoperative threat stratification and intervention.