Indian Journal of Innovative Clinical Research

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EVALUATION OF OXIDATIVE STRESS PARAMETERS IN RELATION TO ANTHROPOMETRIC STATUS AND METABOLIC INDICATORS IN WOMEN WITH PCOS

Article Information

Ritesh Agarwal, Endocrine, Odisha, India

Introduction: Among women of reproductive age, PCOS (polycystic ovarian syndrome) is a prevalent endocrine condition marked by metabolic abnormalities such as insulin resistance and hyperandrogenism. PCOS is linked to oxidative stress and chronic inflammation, which add to the disease's complicated pathophysiology and long-term health hazards. This study aims to assess oxidative stress markers in women with PCOS compared to healthy controls and to evaluate the impact of obesity, hyperandrogenism, and insulin resistance on these markers.

Methods: This study analyzed a cohort of 170 women aged 18 to 46 at a medical facility in Odisha, India, from 2018 to 2020, following the Rotterdam criteria for diagnosing PCOS. Participants included 26 women with PCOS and 21 healthy controls, with assessments involving hormonal, metabolic, and oxidative stress evaluations through blood samples and pelvic ultrasounds. Insulin resistance and free androgen index were calculated using standardized formulas.

Results: In this study, women with PCOS exhibited substantially higher androgen levels and oxidative stress markers, including malondialdehyde and catalase activity, compared to the control group. Hirsutism and acne were observed exclusively in the PCOS cohort, with 29.27% undergoing infertility treatment. Additionally, 48.42% of the PCOS group showed elevated androgen levels or hirsutism, and 43.16% were classified as overweight or obese. Insulin resistance was present in 21.05% of participants, highlighting a complex interplay between hormonal and oxidative stress parameters in PCOS.

Conclusion: The study discovered that women with PCOS had significantly greater levels of androgen and oxidative stress indicators compared to healthy controls. This implies that in this population, oxidative stress and hyperandrogenism might be connected.

Keywords: Polycystic Ovary Syndrome (PCOS), Hyperandrogenism, Oxidative Stress, Malondialdehyde (MDA), Testosterone