Indian Journal of Innovative Clinical Research

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ASSESSING THE EFFECTIVENESS OF AN ECOBIOLOGICAL DERMO-COSMETIC PRODUCT IN MANAGING AND PREVENTING EYELID ATOPIC DERMATITIS RELAPSES

Article Information

Vikas Shankar, MD Skin,VD & Leprosy, Shankar Skin Clinic, Patna, Bihar, India
Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by recurring flare-ups, intense itching, and skin barrier dysfunction. Eyelid AD presents unique challenges due to the delicate nature of the skin around the eyes, limiting the use of traditional treatments like corticosteroids. This study aimed to evaluate the efficacy of a dermo-cosmetic cream (Atoderm Intensive Eye) in alleviating symptoms and preventing relapses of AD on the eyelids.
Methods: A randomized, controlled, double-blind clinical trial was conducted with 120 participants divided into groups for bio metrological analysis, clinical evaluations, and self-assessment. The study assessed the product's effects on AD symptoms such as erythema, dryness, edema, and itching, using a 0–10 severity scale and measuring transepidermal water loss (TEWL) over 168 days. Participants were evaluated at multiple intervals, with half applying the product twice daily and the other half continuing their usual skincare routine.
Results: Participants using Atoderm Intensive Eye showed a significant reduction in AD symptoms, including a 61% improvement in erythema and a 59% reduction in roughness (p < 0.001). TEWL measurements indicated improved skin barrier function by day 28 (p < 0.001). The product group also had significantly fewer AD relapses compared to the control group (0.8 vs. 3.4 relapses, p < 0.001). Quality of life improved, as reflected in lower Dermatological Life Quality Index (DLQI) scores after 28 days (p < 0.001).
Conclusion: The dermo-cosmetic product effectively alleviated AD symptoms and reduced the frequency of relapses, offering a non-steroidal alternative for managing eyelid AD. Its role in improving skin hydration and barrier function highlights its potential for long-term use in AD management.
Keywords: Atopic Dermatitis, Eyelid Dermatitis, Dermo-Cosmetic, Skin Barrier, Transepidermal Water Loss, AD Relapse Prevention